Sirtuin 5 (SIRT5), Human, Recombinant, BiotinylatedSIRT5 (Sirtuin 5) is a member of the SIR2 Sirtuin family of nicotinamide adenine dinucleotide (NAD+) dependent deacetylase enzymes. Sirtuin family enzymes can be found in the cytoplasm, mitochondria or nucleus of a cell and are ubiquitously expressed. SIRT5 has multiple enzymatic functions, such as NAD+ dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins.